pemirolast   Click here for help

GtoPdb Ligand ID: 7329

Synonyms: Alamast® | Alegysal® | BMY-26517
Approved drug
pemirolast is an approved drug (FDA (1999))
Compound class: Synthetic organic
Comment: Pemirolast is an antihistamine.
Marketed formulations may contain pemirolast potassium salt (PubChem CID 443866).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 88.83
Molecular weight 228.08
XLogP 1.81
No. Lipinski's rules broken 0
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Canonical SMILES Cc1cccn2c1ncc(c2=O)c1n[nH]nn1
Isomeric SMILES Cc1cccn2c1ncc(c2=O)c1n[nH]nn1
InChI InChI=1S/C10H8N6O/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8/h2-5H,1H3,(H,12,13,14,15)
No information available.
Summary of Clinical Use Click here for help
Pemirolast is contained in opthalmic solutions used to treat the symptoms of seasonal allergic conjunctivitis, including itching, redness and swelling.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Pemirolast blocks the action of endogenous histamine at histamine H1 receptor. The drug inhibits eosinophil infiltration in the eye and prevents their release of inflammatory mediators.
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