pomalidomide   Click here for help

GtoPdb Ligand ID: 7348

Synonyms: CC-4047 | IMID-3 | Imnovid® | Pomalyst®
Approved drug Immunopharmacology Ligand
pomalidomide is an approved drug (FDA and EMA (2013))
Compound class: Synthetic organic
Comment: Pomalidomide is an analogue of thalidomide with similar immunomodulatory antineoplastic activity.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 109.57
Molecular weight 273.07
XLogP -0.56
No. Lipinski's rules broken 0
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Canonical SMILES O=C1CCC(C(=O)N1)N1C(=O)c2c(C1=O)c(N)ccc2
Isomeric SMILES O=C1CCC(C(=O)N1)N1C(=O)c2c(C1=O)c(N)ccc2
InChI InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
No information available.
Summary of Clinical Use Click here for help
Pomalidomide is approved to treat multiple myeloma. In May 2020, the FDA expanded approval to permit pomalidomide's use to treat Kaposi sarcoma (in HAART-resistant HIV+ve patients or HIV-ve patients).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The mechanism of action of this drug is complex. Its immunomodulatory action may involve inhibition of the production of pro-inflammatory cytokines and inhibition of COX2 transcription [6]. See the DrugBank link for more details. The primary target of pomalidomide (and thalidomide) may be the protein cereblon (CRBM, Q96SW2) [3,5], which has been linked to the teratogenic activity of these drugs [1]. Cereblon has multiple actions, including participation in protein ubiquitination complexes and regulation of potassium channels [2].
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