luliconazole   Click here for help

GtoPdb Ligand ID: 7366

Synonyms: Lulicon® | Luzu® | NND-502 | PR-2699
Approved drug
luliconazole is an approved drug (FDA (2013))
Compound class: Synthetic organic
Comment: Luliconazole is an imidazole antifungal drug.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 92.21
Molecular weight 352.96
XLogP 3.94
No. Lipinski's rules broken 0
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Canonical SMILES N#CC(=C1SCC(S1)c1ccc(cc1Cl)Cl)n1cncc1
Isomeric SMILES N#C/C(=C\1/SC[C@H](S1)c1ccc(cc1Cl)Cl)/n1cncc1
InChI InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1
No information available.
Summary of Clinical Use Click here for help
Used in the treatments of fungal infections caused by Trichophyton rubrum and Epidermophyton floccosum.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The exact mechanism of action of luliconazole is unknown but it is thought to inhibit the enzyme lanosterol demethylase, thereby preventing the synthesis of ergosterol and disrupting fungus cell membrane synthesis.