indacaterol   Click here for help

GtoPdb Ligand ID: 7455

Synonyms: Arcapta Neohaler® | Onbrez® | QAB-149 | QAB149
Approved drug Immunopharmacology Ligand
indacaterol is an approved drug (EMA (2009), FDA (2011))
Compound class: Synthetic organic
Comment: Only the R-enantiomer, as the maleate salt (PubChem CID 9827599) is contained in the medicinal product.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 85.35
Molecular weight 392.21
XLogP 4.65
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CCc1cc2CC(Cc2cc1CC)NCC(c1ccc(c2c1ccc(=O)[nH]2)O)O
Isomeric SMILES CCc1cc2CC(Cc2cc1CC)NC[C@@H](c1ccc(c2c1ccc(=O)[nH]2)O)O
InChI InChI=1S/C24H28N2O3/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29)/t22-/m0/s1
InChI Key QZZUEBNBZAPZLX-QFIPXVFZSA-N
No information available.
Summary of Clinical Use Click here for help
Indacaterol is a very long-acting, rapid onset β2-adrenoceptor agonist [2] approved for the once-daily management of asthma and chronic obstructive pulmonary disease (COPD).
A fixed-dose inhalation combination medicine containing incadaterol and glycopyrrolate (Utibron Neohaler) was approved by the US FDA in November 2015 for the treatment of COPD
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Indacaterol is a highly potent and selective β2-adrenoceptor agonist which acts locally in the lung as a bronchodilator when applied as an inhaled drug. Agonist-induced elevated cAMP levels cause relaxation of bronchial smooth muscle.
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