indacaterol   Click here for help

GtoPdb Ligand ID: 7455

Synonyms: Arcapta Neohaler® | Onbrez® | QAB-149 | QAB149
Approved drug Immunopharmacology Ligand
indacaterol is an approved drug (EMA (2009), FDA (2011))
Compound class: Synthetic organic
Comment: Only the R-enantiomer, as the maleate salt (PubChem CID 9827599) is contained in the medicinal product.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: indacaterol

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 85.35
Molecular weight 392.21
XLogP 4.65
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCc1cc2CC(Cc2cc1CC)NCC(c1ccc(c2c1ccc(=O)[nH]2)O)O
Isomeric SMILES CCc1cc2CC(Cc2cc1CC)NC[C@@H](c1ccc(c2c1ccc(=O)[nH]2)O)O
InChI InChI=1S/C24H28N2O3/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29)/t22-/m0/s1
InChI Key QZZUEBNBZAPZLX-QFIPXVFZSA-N
No information available.
Summary of Clinical Use Click here for help
Indacaterol is a very long-acting, rapid onset β2-adrenoceptor agonist [3] approved for the once-daily management of asthma and chronic obstructive pulmonary disease (COPD).
A fixed-dose inhalation combination medicine containing incadaterol and glycopyrrolate (Utibron Neohaler) was approved by the US FDA in November 2015 for the treatment of COPD
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Indacaterol is a highly potent and selective β2-adrenoceptor agonist which acts locally in the lung as a bronchodilator when applied as an inhaled drug. Agonist-induced elevated cAMP levels cause relaxation of bronchial smooth muscle.
External links Click here for help
For extended ADME data see the following:

Electronic Medicines Compendium (eMC)
Drugs.com
European Medicines Agency (EMA)