deferiprone   Click here for help

GtoPdb Ligand ID: 7456

Synonyms: APO-66 | CP20 | Ferriprox®
Approved drug
deferiprone is an approved drug (EMA (1999), FDA (2011))
Compound class: Synthetic organic
Comment: Deferiprone is an iron-chelating drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 42.23
Molecular weight 139.06
XLogP 2.57
No. Lipinski's rules broken 0
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Canonical SMILES Cn1ccc(=O)c(c1C)O
Isomeric SMILES Cn1ccc(=O)c(c1C)O
InChI InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3
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Summary of Clinical Use Click here for help
Patients with thalassaemia often require repeated blood transfusions to maintain red blood cell levels, but this type of treatment can lead to potentially fatal iron overload.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Deferiprone chelates the excess iron in thalassemia patients [1], and effects its removal and excretion.
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