Ligand id: 7483

Name: solifenacin

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 32.78
Molecular weight 362.2
XLogP 3.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Solifenacin is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.
Mechanism Of Action and Pharmacodynamic Effects
Solifenacin is a competitive cholinergic receptor antagonist. Antagonism of muscarinic acetlycholine receptors (in particular the M2 and M3 subtypes) in the bladder reduces tonus (elastic tension) of the urinary bladder and slows parasympathetic contractions. This relieves the symptoms associated with overactive bladder syndrome by increasing bladder capacity and decreasing urinary urgency.
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