alcaftadine   Click here for help

GtoPdb Ligand ID: 7587

Synonyms: Lastacaft® | R-89674
Approved drug Immunopharmacology Ligand
alcaftadine is an approved drug (FDA (2010))
Compound class: Synthetic organic
Comment: Alcaftadine is an antihistamine drug.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 38.13
Molecular weight 307.17
XLogP 2.45
No. Lipinski's rules broken 0
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Canonical SMILES O=Cc1cnc2n1CCc1c(C2=C2CCN(CC2)C)cccc1
Isomeric SMILES O=Cc1cnc2n1CCc1c(C2=C2CCN(CC2)C)cccc1
InChI InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3
No information available.
Summary of Clinical Use Click here for help
Used in an opthalmic solution to treat the symptoms of allergic conjunctivitis.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Alcaftadine blocks the action of endogenous histamine at the histamine H1 receptor.
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