dexbrompheniramine   Click here for help

GtoPdb Ligand ID: 7588

Synonyms: D-brompheniramine | Disomer®
Approved drug
dexbrompheniramine is an approved drug (FDA)
Compound class: Synthetic organic
Comment: Chemically, dexbrompheniramine is the pharmacologically active dextrorotatory isomer of brompheniramine.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 16.13
Molecular weight 318.07
XLogP 3.41
No. Lipinski's rules broken 0
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Canonical SMILES CN(CCC(c1ccccn1)c1ccc(cc1)Br)C
Isomeric SMILES CN(CC[C@H](c1ccccn1)c1ccc(cc1)Br)C
InChI InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1
No information available.
Summary of Clinical Use Click here for help
Used to treat allergic conditions such as hay fever or urticaria.
Drugs@FDA lists oral, single agent dexbrompheniramine medications as discontinued. Individual national approval agencies may have granted marketing authorisation for this drug.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Dexbrompheniramine blocks the action of endogenous histamine at the histamine H1 receptor. This drug may also have anticholingeric /antimuscarinic action which is likely to contribute to the drug's side effects, which include drowsiness, dry mouth and throat and increased heart rate.