Synonyms: 13-cis retinoic acid
isotretinoin is an approved drug (FDA (1982))
Compound class:
Synthetic organic
Comment: Isotretinoin is a retinoid type drug ie it is a vitamin A-like molecule. It is the endogenous agonist for retinoic acid receptors (RARs).
![]() View more information in the IUPHAR Pharmacology Education Project: isotretinoin |
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No information available. |
Summary of Clinical Use ![]() |
Primarily used to treat cystic acne. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Isotretinoin has a low affinity for retinoic acid receptors (RAR) and retinoid X receptors (RXR), but metabolites may act as agonists of these nuclear receptors [1]. Activation of RAR modulates the expression of genes essential for regulating cell proliferation and differentiation. Isotretinoin may also posess immunomodulatory and anti-inflammatory activities and has been demonstrated to inhibit ornithine decarboxylase, an action likely to decrease polyamine synthesis and keratinization. |
External links ![]() |
For extended ADME data see the following: Drugs.com |