fludroxycortide   Click here for help

GtoPdb Ligand ID: 7606

Synonyms: Cordran® | flurandrenolide | flurandrenolone | Haelan®
Approved drug Immunopharmacology Ligand
fludroxycortide is an approved drug (FDA (1963))
Compound class: Synthetic organic
Comment: Fludroxycortide is a synthetic topical glucocorticoid, used clinically for its antiinflammatory action [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 93.06
Molecular weight 436.23
XLogP 0.65
No. Lipinski's rules broken 0
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Isomeric SMILES OCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@H]2[C@H]1C[C@@H](C1=CC(=O)CC[C@]21C)F)(C)C
InChI InChI=1S/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,26,28H,5-6,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
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Summary of Clinical Use Click here for help
Fludroxicortide is a topical corticosteroid drug. It is used to relieve inflammatory and pruritic symptoms of corticosteroid-responsive skin conditions.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Fludroxicortide is a glucocorticoid receptor (GR) agonist. The GR-drug complex translocates to the nucleus where it transactivates the expression of genes containing glucocorticoid response elements (GREs). Target genes include those for anti-inflammatory proteins and the net effect is a reduction of prostaglandin and leukotriene biosynthesis.
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