phensuximide   Click here for help

GtoPdb Ligand ID: 7612

Synonyms: Lifene® | Milontin®
Compound class: Synthetic organic
Comment: Phensuximide is a racemic mixture of enantiomers; R-phensuximide and S-phensuximide. We show the non-stereo molecule to represent the mixture. One tautomer is also recognised, with PubChem CID 53881854
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 37.38
Molecular weight 189.08
XLogP 0.66
No. Lipinski's rules broken 0
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Canonical SMILES CN1C(=O)CC(C1=O)c1ccccc1
Isomeric SMILES CN1C(=O)CC(C1=O)c1ccccc1
InChI InChI=1S/C11H11NO2/c1-12-10(13)7-9(11(12)14)8-5-3-2-4-6-8/h2-6,9H,7H2,1H3
No information available.
Summary of Clinical Use Click here for help
Phensuximide is a succinimide anticonvulsant, used to treat epileptic seizures.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The precise MMOA of phensuximide has not been fully resolved. The drug has been reported to Inhibit the activity of the voltage-dependent T-type calcium channels Cav3.1 (CACNA1G), Cav3.2 (CACNA1H) and Cav3.3 (CACNA1I) and also inhibits depolarization-induced accumulation of cyclic AMP and cyclic GMP (as demonstrated in mouse cerebral cortex slices [1])