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Synonyms: Androxal® | enclomiphene citrate
Compound class: Synthetic organic
Comment: Enclomiphene is the trans isomer component in the racemate drug clomiphene and has also been assigned an INN in its own right.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Enclomiphene is under investigation as a treatment for men of reproductive age with low testosterone due to secondary hypogonadism [2-3]. ClinicalTrials.gov hosts a list of all currently registered trials assessing this potential drug (as Androxal® aka enclomiphene citrate).
Enclomiphene is an active component of the approved drug clomiphene. See the ligand page for enclomiphene for details of its clinical use and mechanism of action.
|Mechanism Of Action and Pharmacodynamic Effects|
|Enclomiphene is an oral therapy designed to treat the inadequate pituitary hormone levels which cause secondary hypogonadism. This provides a more convenient way of taking this treatment, as opposed to traditional testosterone replacement therapy which is administered by injection or in gels.
See the ligand page for clomiphene for details of its mechanism of action.