enclomiphene   Click here for help

GtoPdb Ligand ID: 7619

Synonyms: Androxal® | enclomiphene citrate
PDB Ligand
Compound class: Synthetic organic
Comment: Enclomiphene is the trans isomer component in the racemate drug clomiphene and has also been assigned an INN in its own right.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 12.47
Molecular weight 405.19
XLogP 7.28
No. Lipinski's rules broken 1
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Canonical SMILES CCN(CCOc1ccc(cc1)C(=C(c1ccccc1)Cl)c1ccccc1)CC
Isomeric SMILES CCN(CCOc1ccc(cc1)/C(=C(\c1ccccc1)/Cl)/c1ccccc1)CC
InChI InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25+
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Summary of Clinical Use Click here for help
Enclomiphene is under investigation as a treatment for men of reproductive age with low testosterone due to secondary hypogonadism [2-3]. ClinicalTrials.gov hosts a list of all currently registered trials assessing this potential drug (as Androxal® aka enclomiphene citrate).
Enclomiphene is an active component of the approved drug clomiphene. See the ligand page for enclomiphene for details of its clinical use and mechanism of action.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Enclomiphene is an oral therapy designed to treat the inadequate pituitary hormone levels which cause secondary hypogonadism. This provides a more convenient way of taking this treatment, as opposed to traditional testosterone replacement therapy which is administered by injection or in gels.

See the ligand page for clomiphene for details of its mechanism of action.