Ligand id: 7686

Name: AZD5672

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 0
Rotatable bonds 12
Topological polar surface area 111.83
Molecular weight 639.26
XLogP 4.32
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AZD5672 was tested as a potential treatment for rheumatoid arthritis, however, the compound failed to show efficacy in clinical trial, and development was ceased.
Mechanism Of Action and Pharmacodynamic Effects
AZD5672 is an antagonist of the chemokine receptor CCR5 [1]. High levels of CCR5 and its ligands are associated with rheumatoid arthritis [2-3]. Antagonism of CCR5 reduces immunopathological processes driven by activation of this receptor.