Synonyms: AZD 4017 | AZD-4017
Compound class:
Synthetic organic
Comment: AZD4017 is a selective inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) [2-3]. This compound is listed in AstraZeneca's OpenInnovation Pharmacology Toolbox .
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use ![]() |
AZD4017 was originally investigated as a potential treatment for cardiovascular and metabolic disorders, in particular diabetes. Click here to view AZD4017 trials registered with ClinicalTrials.gov. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Inhibition of 11β-HSD1 reduces circulating levels of the glucocorticoid, cortisol. Elevated levels of intracellular glucocorticoids are thought to underlie the metabolic syndrome [1] which can progress to type II diabetes [4-5]. |