AZD1208   Click here for help

GtoPdb Ligand ID: 7698

Synonyms: AZD 1208 | AZD-1208
Compound class: Synthetic organic
Comment: AZD1208 inhibits all members of the proviral integration Moloney virus (PIM) serine/threonine kinase family, that was intended for use as an anticancer drug [1-2]. This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 100.73
Molecular weight 379.14
XLogP 3.51
No. Lipinski's rules broken 0
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Canonical SMILES NC1CCCN(C1)c1c(cccc1c1ccccc1)C=C1SC(=O)NC1=O
Isomeric SMILES N[C@@H]1CCCN(C1)c1c(cccc1c1ccccc1)/C=C/1\SC(=O)NC1=O
InChI InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1
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Summary of Clinical Use Click here for help
AZD1208 progressed to Phase 1 clinical evaluation but the compound was not developed further. Click here to link to's full list of AZD1208 trials.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
AZD1208 was developed with the aim of inhibiting abberant PIM kinase activity which has been reported to be upregulated in several types of leukemias and lymphomas.