Ligand id: 7815

Name: dilmapimod

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 99.75
Molecular weight 456.14
XLogP 4.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
SB-681323 has been assessed to Phase II in clinical trial for indications including chronic obstructive pulmonary disease, rheumatoid arthritis and neuropathic pain, although there are no currently active trials (as of Nov 2014). Click here to view the list of completed SB-681323 trials at ClinicalTrials.gov.
Mechanism Of Action and Pharmacodynamic Effects
The molecular target of dilmapimod is p38 MAPK.