riviciclib   Click here for help

GtoPdb Ligand ID: 7934

Synonyms: P276-00 [1]
Compound class: Synthetic organic
Comment: Riviciclib is a flavone based cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 94.14
Molecular weight 401.1
XLogP 3.95
No. Lipinski's rules broken 0
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Canonical SMILES OCC1N(C)CCC1c1c(O)cc(c2c1oc(cc2=O)c1ccccc1Cl)O
Isomeric SMILES OC[C@@H]1N(C)CC[C@H]1c1c(O)cc(c2c1oc(cc2=O)c1ccccc1Cl)O
InChI InChI=1S/C21H20ClNO5/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3/t12-,14+/m1/s1
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Summary of Clinical Use Click here for help
Riviciclib has been assessed in several Phase 2 clinical trials, although development has not progressed further. Indications included pancreatic cancer, squamous cell head and neck cancer, relapsed and/or refractory multiple myeloma and mantle cell lymphoma. Click here to link to ClinicalTrials.gov's list of riviciclib trials.