PF-04691502

Ligand id: 7936

Name: PF-04691502

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 125.38
Molecular weight 425.21
XLogP 2.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Phase 2 clinical trials assessing PF-04691502 for breast and endometrial neoplasms have been withdrawn or terminated. As of October 2018 ClinicalTrials.gov has no record of active PF-04691502 studies.
Mechanism Of Action and Pharmacodynamic Effects
Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. Inhibition of PI3K and mTOR kinases may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR.