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Synonyms: PP 121 | PP-121
Compound class: Synthetic organic
Comment: PP121 is a multi-targeted kinase inhibitor, discovery of which is described in , where it is compound 6. It is designed to target tyrosine kinases and phosphatidylinositol-3 kinases (PI3Ks), a set of interconnected oncogenes, that are of intense interest as molecular targets in the drug discovery process.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.
|Mechanism Of Action and Pharmacodynamic Effects
|PP121 selectivity interacts within a hydrophobic pocket that is conserved between both tyrosine kinases and PI3Ks, but not serine-threonine kinases .