anifrolumab   Click here for help

GtoPdb Ligand ID: 8258

Synonyms: MDX-1333 | MEDI-546
Immunopharmacology Ligand
Compound class: Antibody
Comment: Anifrolumab is a monoclonal antibody targeting IFNAR1 (the receptor for α, β and ω interferons), being developed by the MedImmune subsidiary of AstraZeneca as a treatment for systemic lupus erythematosus (SLE).
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. [3]. Sequence BLAST using the heavy and light chain variable regions of anifrolumab provides 100% matches to sequences patented with application US7662381 [3]. The sequence matches identify anifrolumab as clone 11E2 in the patent.
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No information available.
Summary of Clinical Use Click here for help
Anifrolumab has reached Phase III clinical development for SLE (NCT02446912, NCT02446899) and Phase I for scleroderma (NCT00930683).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
IFNα appears to enhance the maturation or activation of dendritic cells (DCs) [6-10], and increased expression of type I interferons has been described in several autoimmune diseases including SLE [1-2,5,11] and insulin-dependent diabetes mellitus (IDDM) [4]. Pharmaceutical intervention options to combat elevated IFNα levels include neutralising circulating IFNα (as achieved by sifalimumab) or blocking/competitively inhibiting IFNα binding to its cognate receptor. The latter is the mechanism by which anifrolumab acts.