elotuzumab   

GtoPdb Ligand ID: 8361

Synonyms: BMS-901608 | Empliciti® | HuLuc63
elotuzumab is an approved drug (FDA (2015), EMA (2016))
Compound class: Antibody
Comment: Elotuzumab is a humanized IgG1 antibody targeting CS1 (SLAMF7) [1-2].
Peptide sequences for elotuzumab are available from its IMGT/mAb-DB record.
No information available.
Summary of Clinical Use
Following evaluation in Phase III clinical trial for MM, which tested various combinations of lenalidomide, dexamethasone or bortezomib ± elotuzumab [3-4], the US FDA approved the elotuzumab/lenalidomide/dexamethasone combination in late 2015. Use is indicated for MM patients who have received one to three prior therapies.
In the European Union elotuzumab has had orphan drug designation since August 2012, for the treatment of MM.
Mechanism Of Action and Pharmacodynamic Effects
CS1 is present in particularly high levels on the plasma cells from patients with MM [2]. Elotuzumab engagement of CS1 effectively activates the body's immune system to attack and kill MM cells by inducing antibody-dependent cellular cytotoxicity (ADCC) against them [2].
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