etelcalcetide   Click here for help

GtoPdb Ligand ID: 8375

Synonyms: AMG 416 | AMG-416 | KAI-4169 | Parsabiv® | velcalcetide
Approved drug
etelcalcetide is an approved drug (EMA (2016), FDA (2017))
Comment: Etelcalcetide is a novel calcimimetic, peptidic agonist of the human cell surface calcium-sensing receptor (CaSR) [1]. The chemical structure shown here was generated using the SMILES from PubChem CID 71511839.
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2D Structure
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Canonical SMILES NC(=NCCC[C@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N)CCCN=C(N)N)C)CCCN=C(N)N)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)C)CSSC[C@@H](C(=O)O)N)C)CCCN=C(N)N)N
Isomeric SMILES C[C@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](C)NC(=O)[C@@H](CSSC[C@@H](C(=O)O)N)NC(=O)C
InChI InChI=1S/C38H73N21O10S2/c1-18(28(62)56-22(27(40)61)8-4-12-49-35(41)42)53-30(64)23(9-5-13-50-36(43)44)58-32(66)25(11-7-15-52-38(47)48)59-31(65)24(10-6-14-51-37(45)46)57-29(63)19(2)54-33(67)26(55-20(3)60)17-71-70-16-21(39)34(68)69/h18-19,21-26H,4-17,39H2,1-3H3,(H2,40,61)(H,53,64)(H,54,67)(H,55,60)(H,56,62)(H,57,63)(H,58,66)(H,59,65)(H,68,69)(H4,41,42,49)(H4,43,44,50)(H4,45,46,51)(H4,47,48,52)/t18-,19-,21+,22-,23-,24-,25-,26-/m1/s1
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Summary of Clinical Use Click here for help
Etelcalcetide (AMG 416) was approved by the EMA in 2016, and later by the US FDA in Feb. 2017 for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis. Click here to link to's listing of Phase 3 AMG 416 trials.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The calcimimetic mechanism of etelcalcetide is distinct from that of the approved drug cinacalcet which is an allosteric modulator of the CaSR.
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