bimiralisib

Ligand id: 8383

Name: bimiralisib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 102.52
Molecular weight 411.16
XLogP 1.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
PQR309 is being evaluated in Phase I clinical trials in patients with various advanced solid tumors (NCT01940133) and relapsed or refractory lymphomas (NCT02249429).
Mechanism Of Action and Pharmacodynamic Effects
The PI3K signaling pathway is frequently activated in tumors and promotes oncogenic cell transformation, proliferation and tumor growth. Pharmaceutical companies are actively developing novel and selective PI3K inhibitors, such as PQR309, for use in oncology.