AMG319   Click here for help

GtoPdb Ligand ID: 8917

Synonyms: AMG 319 | AMG-319
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: AMG319 is an inhibitor of phosphoinositide 3-kinase δ (PI3Kδ) inhibitor, with potential clinical anti-inflammatory utility [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 92.27
Molecular weight 385.15
XLogP 3.49
No. Lipinski's rules broken 0
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Canonical SMILES Fc1ccc2c(c1)nc(c(c2)C(Nc1ncnc2c1[nH]cn2)C)c1ccccn1
Isomeric SMILES Fc1ccc2c(c1)nc(c(c2)[C@@H](Nc1ncnc2c1[nH]cn2)C)c1ccccn1
InChI InChI=1S/C21H16FN7/c1-12(28-21-19-20(25-10-24-19)26-11-27-21)15-8-13-5-6-14(22)9-17(13)29-18(15)16-4-2-3-7-23-16/h2-12H,1H3,(H2,24,25,26,27,28)/t12-/m0/s1
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Summary of Clinical Use Click here for help
AMG319 is being evaluated in Phase 2 clinical trial for its potential as a treatment for human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC)- see NCT02540928.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02540928 AMG 319 in HPV Positive and Negative HNSCC Phase 2 Interventional Cancer Research UK