Synonyms: AMG 319 | AMG-319
Compound class:
Synthetic organic
Comment: AMG319 is an inhibitor of phosphoinositide 3-kinase δ (PI3Kδ) inhibitor, with potential clinical anti-inflammatory utility [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use ![]() |
AMG319 is being evaluated in Phase 2 clinical trial for its potential as a treatment for human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC)- see NCT02540928. |
Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT02540928 | AMG 319 in HPV Positive and Negative HNSCC | Phase 2 Interventional | Cancer Research UK |