pepinemab   Click here for help

GtoPdb Ligand ID: 8932

Synonyms: mAb 62-7 | VX15/2503
Compound class: Antibody
Comment: Pepinemab (VX15/2503) is an investigational humanized IgG4 monoclonal antibody targeting semaphirin 4D (SEMA4D) [1].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
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Summary of Clinical Use Click here for help
VX15/2503 is in clinical development as a novel therepeutic for various malignancies and neurodegenerative disorders, including multiple sclerosis and Huntington's disease.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02481674 A Study in Subjects With Late Prodromal and Early Manifest Huntington's Disease (HD) to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of Pepinemab (VX15/2503) Phase 2 Interventional Vaccinex Inc.