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Synonyms: mAb 62-7 | VX15/2503
Compound class:
Antibody
Comment: Pepinemab (VX15/2503) is an investigational humanized IgG4 monoclonal antibody targeting semaphirin 4D (SEMA4D) [1].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. 
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Bioactivity Comments |
| VX15/2503 binds soluble and cellular SEMA4D of human, rabbit, cynomolgus macaque, marmoset, rhesus macaque, rat and mouse origin and blocks binding of SEMA4D to all three of its known receptors, PLXNB1, PLXNB2, and CD72 [1]. Epitope mapping suggests that VX15/2503 binds a functionally important region of SEMA4D, and may sterically hinder SEMA4D-plexinB1 interactions and/or inhibit SEMA4D homodimerisation (required for semaphorin-plexin signalling). VX15/2503 does not cause cytokine storm, a liability factor for human therapeutic antibodies [1]. |
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