GtoPdb Ligand ID: 8932

Synonyms: mAb 62-7
Compound class: Antibody
Comment: VX15/2503 is an investigational humanized IgG4 monoclonal antibody targeting semaphirin 4D (SEMA4D) [1].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Bioactivity Comments
VX15/2503 binds soluble and cellular SEMA4D of human, rabbit, cynomolgus macaque, marmoset, rhesus macaque, rat and mouse origin and blocks binding of SEMA4D to all three of its known receptors, PLXNB1, PLXNB2, and CD72 [1]. Epitope mapping suggests that VX15/2503 binds a functionally important region of SEMA4D, and may sterically hinder SEMA4D-plexinB1 interactions and/or inhibit SEMA4D homodimerisation (required for semaphorin-plexin signalling). VX15/2503 does not cause cytokine storm, a liability factor for human therapeutic antibodies [1].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
semaphorin 4D (CD100) Hs Antibody Binding 9.4 pKd - 1
pKd 9.4 (Kd 4.5x10-10 M) [1]
Description: Measuring binding to native SEMA4D expressed on human peripheral blood T lymphocytes.