Ligand id: 8999

Name: (S)-ARN2508

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 75.63
Molecular weight 387.18
XLogP 5.68
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
FAAH catalyzes the hydrolysis of anandamide, generating arachidonic acid (AA), which is the substrate of COX. Multi-targeted agents that simultaneously act to inhibit FAAH and COX are being investigated as novel anti-inflammatory therapeutics for the treatment of pain [4]. Concomitant inhibition of FAAH and COX enhances the analgesic effect of NSAIDs ('coxibs') [2], and in addition FAAH inhibition reduces the adverse gastrointestinal side effects caused by COX inhibition [5].