Synonyms: Colofac® | CSAG-144 | Duspatalin®
mebeverine is an approved drug (UK (1978))
Compound class:
Synthetic organic
Comment: Mebeverine is a musculotropic antispasmodic drug. Marketed formulations contain the hydrochloride salt (PubChem CID 17683) which is sometimes combined with ispaghula husk (sold as Fybogel®) to add fibre to the gut contents.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: mebeverine |
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No information available. |
Summary of Clinical Use |
Mebeverine is approved to treat the abdominal cramping associated with irritable bowel syndrome (IBS) and associated conditions. It is a generic drug available internationally under many brand names (see Drugs.com's international drug page for mebeverine). In many countries this is sold as an over the counter (OTC) drug. |
Mechanism Of Action and Pharmacodynamic Effects |
Mebeverine is an antimuscarinic agent acting on gut receptors to relax the intestinal smooth muscle, without affecting motility. |
External links |
For extended ADME data see the following: Electronic Medicines Compendium (eMC) |