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Synonyms: KHK-7580 | MT-4580
Compound class: Synthetic organic
Comment: Evocalcet is an investigational calcium-sensing receptor (CASR) agonist, or calcimimetic. CASR is a G protein-coupled receptor.
This compound is claimed in patent US8362274 .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Evocalcet (KHK7580) is being evaluated in Phase 3 clinical trial for the treatment of hemodialysis patients with secondary hyperparathyroidism. Click here to link to ClinicalTrials.gov's full list of KHK7580 trials.|
|Mechanism Of Action and Pharmacodynamic Effects|
|CASR agonists act to suppress parathyroid hormone (PTH) production.|