megestrol   Click here for help

GtoPdb Ligand ID: 9128

Synonyms: Chronopil | Magestin | Megace® | megestryl acetate
Approved drug
megestrol is an approved drug (FDA (1971))
Compound class: Synthetic organic
Comment: Megestrol (commonly administered as the acetate ester: PubChem CID 11683) is a synthetic derivative of the female sex hormone progesterone. It has anti-estrogenic and antineoplastic activity.
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: megestrol

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 54.37
Molecular weight 342.22
XLogP 3.31
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES O=C1CCC2(C(=C1)C(=CC1C2CCC2(C1CCC2(O)C(=O)C)C)C)C
Isomeric SMILES O=C1CC[C@]2(C(=C1)C(=C[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@]2(O)C(=O)C)C)C)C
InChI InChI=1S/C22H30O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h11-12,16-18,25H,5-10H2,1-4H3/t16-,17+,18+,20-,21+,22+/m1/s1
No information available.
Summary of Clinical Use Click here for help
Megestrol is approved to treat anorexia and cachexia and is also used in the treatment of advanced breast and endometrial cancers.
External links Click here for help