Ligand id: 9134

Name: GSK583

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 96.12
Molecular weight 398.12
XLogP 4.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
The pathway signalling via NOD1 and NOD2 is implicated in several inflammatory disorders, including inflammatory bowel disease (IBD), rheumatoid arthritis, sarcoidosis and asthma. Activation of NOD1 and NOD2 stimulates the synthesis of pro-inflammatory mediators. RIP2 kinase is the convergence point for NOD1/NOD2 signalling, so represents novel target for pharmacological regulation of aberrant NOD1/NOD2 activation in inflammatory disease.