pizotifen   Click here for help

GtoPdb Ligand ID: 93

Synonyms: BC-105 | pizotifan | pizotyline | sandomigran
Approved drug
pizotifen is an approved drug (UK (1998))
Compound class: Synthetic organic
Comment: Pizotifen is a benzocycloheptene-based anti-migraine drug, acting principally as an antagonist of serotonin 5-HT2A and 5-HT2C receptors.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 31.48
Molecular weight 295.14
XLogP 2.98
No. Lipinski's rules broken 0
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Canonical SMILES CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1
Isomeric SMILES CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1
InChI InChI=1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3
No information available.
Summary of Clinical Use Click here for help
Pizotifen is not approved by the US FDA or EMA. In the UK, pizotifen hydrogen malate (PubChem CID 168993) is sold as generic tablets, or as Sanomigran® tablets for the prophylactic treatment of migraine and cluster headaches.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Pizotifen acts predominantly as a serotonin antagonist, acting mainly at the 5-HT2A and 5HT2C receptors, with minor antihistamine and anticholinergic activity