citarinostat   Click here for help

GtoPdb Ligand ID: 9426

Synonyms: ACY-241 | Compound (I) [WO2016200919] [2] | HDAC-IN-2
Compound class: Synthetic organic
Comment: Citarinostat (ACY-241) is a next-generation HDAC6 inhibitor, that is under investigation for potential antineoplastic activity [1]. Note that it exhibits only ~10-fold enzymic selectivity against the class I isoform, HDAC1.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 107.45
Molecular weight 467.17
XLogP 4.36
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1Cl)c1ccccc1
Isomeric SMILES ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1Cl)c1ccccc1
InChI InChI=1S/C24H26ClN5O3/c25-20-12-7-8-13-21(20)30(19-10-4-3-5-11-19)24-27-16-18(17-28-24)23(32)26-15-9-2-1-6-14-22(31)29-33/h3-5,7-8,10-13,16-17,33H,1-2,6,9,14-15H2,(H,26,32)(H,29,31)
InChI Key VLIUIBXPEDFJRF-UHFFFAOYSA-N
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Summary of Clinical Use Click here for help
ACY-241 is in Phase 1 clinical trial in combination treatments for multiple myeloma, malignant melanoma, non-small cell lung cancer (NSCLC) and other solid tumours. Click here to link to ClinicalTrials.gov's list of ACY-241 trials.