mapracorat   Click here for help

GtoPdb Ligand ID: 9654

Synonyms: BOL-303242-X | ZK-245186 | ZK245186
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist (SEGRA) [3-4]. SEGRAs exert their pharmacological effect by activating only the transrepression pathway, which is in contrast to traditional glucocorticosteroids (GCs) which activate both the transactivation and transrepression pathways.The pharmaceutical industry is trying to develop new GCs that are as effective as traditional GCs, but with fewer limiting adverse effects. Mapracorat and GSK866 are prototype compounds that were designed to address this clinical need.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 54.38
Molecular weight 462.19
XLogP 5.9
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Fc1cc2CCOc2c(c1)C(CC(C(F)(F)F)(CNc1cccc2c1ccc(n2)C)O)(C)C
Isomeric SMILES Fc1cc2CCOc2c(c1)C(C[C@](C(F)(F)F)(CNc1cccc2c1ccc(n2)C)O)(C)C
InChI InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m1/s1
InChI Key VJGFOYBQOIPQFY-XMMPIXPASA-N
No information available.
Summary of Clinical Use Click here for help
Mapracorat was investigated for the topical treatment of ocular inflammation, reaching Phase 3 trial, for example NCT01230125 which evaluated mapracorat as management of ocular inflammation following cataract surgery. It also reached Phase 2 for atopic dermatitis, with several trials completed.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT01230125 Mapracorat Ophthalmic Suspension for the Treatment of Ocular Inflammation Following Cataract Surgery Phase 3 Interventional Bausch & Lomb Incorporated