Synonyms: Serdolect® | Serlect® | sertindol
sertindole is an approved drug
Compound class:
Synthetic organic
Comment: Sertindole is an atypical antipsychotic medication, functioning as a dopamine D2 and serotonin 5-HT2 receptor antagonist.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Summary of Clinical Use ![]() |
Atypical antipsychotic used in the treatment of schizophrenia. Although this drug was withdrawn in some countries due to concerns over cardiovascular adverse effects, some national regulatory authorities maintain approval, such as in Australia where sertindole is indicated only for treatment of patients whose schizophrenia is not responsive to, or who are intolerant of other antipsychotic medicines. This drug is not approved in the US. In October 2001, the EMA lifted a marketing suspension, but imposed restrictions on the approval (click here to view the EMA's summary/review of sertindole's marketing authorisation). |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Antagonist at a range of GPCRs, namely dopamine D2 receptors, serotonin 5-HT2A and 5-HT2C receptors and α1-adrenoceptors. |