DX-2507   Click here for help

GtoPdb Ligand ID: 9959

Immunopharmacology Ligand
Compound class: Antibody
Comment: DX-2507 is a fully human anti-FcRn monoclonal antibody [2] that was originally developed by Dyax Corporation, and is being progressed by Shire following their acquisition of Dyax.
A X-ray crystal structure of DX-2507-Fab in complex with FcRn has been published [1]. The Protein Data Bank identifier for the 2.15Å structure of unbound DX-2507-Fab is 5WHJ.
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No information available.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Disrupting binding of IgG antibodies to FcRn drives the IgG towards the lysosomal degradation pathway, increases IgG catabolism and ultimately depletes circulating IgG levels [2].