DX-2507   Click here for help

GtoPdb Ligand ID: 9959

Immunopharmacology Ligand
Compound class: Antibody
Comment: DX-2507 is a fully human anti-FcRn monoclonal antibody [2] that was originally developed by Dyax Corporation, and is being progressed by Shire following their acquisition of Dyax.
A X-ray crystal structure of DX-2507-Fab in complex with FcRn has been published [1]. The Protein Data Bank identifier for the 2.15Å structure of unbound DX-2507-Fab is 5WHJ.
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1. Kenniston JA, Taylor BM, Conley GP, Cosic J, Kopacz KJ, Lindberg AP, Comeau SR, Atkins K, Bullen J, TenHoor C et al.. (2017)
Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J Biol Chem, 292 (42): 17449-17460. [PMID:28878017]
2. Nixon AE, Chen J, Sexton DJ, Muruganandam A, Bitonti AJ, Dumont J, Viswanathan M, Martik D, Wassaf D, Mezo A et al.. (2015)
Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates.
Front Immunol, 6: 176. [PMID:25954273]