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Synonyms: compound 57 [PMID: 30106292]
Compound class: Synthetic organic
Comment: LIT-927 is a small molecule that binds to and neutralises the chemokine CXCL12 . It has been termed a 'neutraligand'. LIT-927 was developed as an alternative strategy to inhibitors for CXCL12's cognate receptors CXCR4 or CXCR7, as a potential anti-inflammatory agent.
|LIT-927 exhibits high binding selectivity for CXCL12 over other chemokines. Orally delivered LIT-927 reduces eosinophil recruitment in a murine model of allergic airway hypereosinophilia, indicating potential efficacy as an anti-asthmatic agent . It offers a pharmacological tool that is suitable for the investigation of CXCL12 physiology in vivo and for further exploration of the utility/efficacy of chemokine neutralisation as a pharmacological strategy in inflammatory and related diseases.|