- Advanced search
- Immuno Portal
- Malaria Portal
Compound class: Synthetic organic
Comment: Compound 31 is a selective antagonist of CCR4 .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound 31 was designed to examine the potential of small molecule CCR4 antagonists as immuno-oncology drugs. It was found to reduce trafficking of Treg cells to the tumour microenvironment but did not inhibit their migration to the spleen, which suggests that compound 31 may not disrupt crucial immune functions of Treg in healthy, non-target tissues .|