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Synonyms: CD24-Fc [2] | CD24Fc
Compound class:
Peptide or derivative
Comment: MK-7110 (originally OncoImmune's CD24Fc) is a synthetic protein that fuses the nonpolymorphic regions of CD24 (which is an agonist of Siglec-10) to the Fc region of human IgG1 [2]. It.is being investigated as a modulator of the innate immune system, originally as an intervention to ameliorate graft-versus-host disease in leukemia patients receiving stem cell transplants, or autoimmune diseases. The peptide's sequence was extracted from OncoImmune's patent US20130231464A1 [4]; the first 30 amino acids are the CD24 region and the remainder belong to the IgG1 Fc domain.
SARS-CoV-2 and COVID-19: Preclinical evidence in primate viral infection models showed that MK-7110 offered potential as a non-antiviral biological modality that could be applied to reduce inflammation in SARS-CoV-2 infection. |
| Immunopharmacology Comments |
| The interaction of Siglec-10 (Siglec-G is the mouse paralogue) on T cells with CD24 is critical for repressing DAMP-mediated amplification of T cell responses. As a CD24 mimetic MK-7110 is designed to enhance Siglec-10/CD24 signalling. In vitro evidence shows that MK-7110 acts as an agonist of Siglec-10 signalling, and that enhancing this pathway functionally blocks DAMP-mediated stimulation of innate immune responses (particularly negatively regulating T cell responses) [3]. MK-7110 reduces the production of multiple inflammatory cytokines, in primate models of viral infections. It also reverses loss of T lymphocytes and functional T cell exhaustion, and reduces leukocyte infiltration of multiple organs in these animals. |
