MK-7110   Click here for help

GtoPdb Ligand ID: 11395

Synonyms: CD24-Fc [2] | CD24Fc
Immunopharmacology Ligand
Comment: MK-7110 (originally OncoImmune's CD24Fc) is a synthetic protein that fuses the nonpolymorphic regions of CD24 (which is an agonist of Siglec-10) to the Fc region of human IgG1 [2]. being investigated as a modulator of the innate immune system, originally as an intervention to ameliorate graft-versus-host disease in leukemia patients receiving stem cell transplants, or autoimmune diseases. The peptide's sequence was extracted from OncoImmune's patent US20130231464A1 [4]; the first 30 amino acids are the CD24 region and the remainder belong to the IgG1 Fc domain.

SARS-CoV-2 and COVID-19: Preclinical evidence in primate viral infection models showed that MK-7110 offered potential as a non-antiviral biological modality that could be applied to reduce inflammation in SARS-CoV-2 infection.
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
sialic acid binding Ig like lectin 10 Hs Agonist Agonist - - - 4