nurulimab   Click here for help

GtoPdb Ligand ID: 12992

Synonyms: BCD-145 | BCD145
Immunopharmacology Ligand
Compound class: Antibody
Comment: Nurulimab (BCD-145) is a human IgG1 anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) monoclonal antibody. It blocks the interaction between CTLA4 and its ligands CD80 and CD86, which establishes an inhibitory immune checkpoint. Blocking this checkpoint offers therapeutic potential as this mechanism stimulates the immune system to destroy cancer cells.
Immunopharmacology Comments
Blocking the CTLA4-CD80/86 checkpoint induces an endogenous immune response against cancer cells.