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Abbreviated name: RvE1
Synonyms: 5S,12R,18R‐trihydroxy‐6Z,8E,10E,14Z,16E‐eicosapentaenoic acid
Compound class: Metabolite or derivative
Comment: This is an E-series resolvin.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Resolvins are a group of autacoid mediators that are derived from either docosahexaenoic acid (D-series) or eicosapentaenoic acid (E-series). They promote resolution of inflammation.
RvE1 is a more potent regulator of leukocyte responses than aspirin and dexamethasone. RvE1 also exhibits antinociceptive actions that reduce inflammatory pain [3-4] more effectively than the COX‐2 inhibitor NS-398 and morphine .