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Abbreviated name: RvE1
Synonyms: 5S,12R,18R‐trihydroxy‐6Z,8E,10E,14Z,16E‐eicosapentaenoic acid
Compound class: Metabolite or derivative
Comment: This is an E-series resolvin.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN. (2005)
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.
J Exp Med, 201 (5): 713-22. [PMID:15753205]
2. Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CN. (2007)
Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation.
J Immunol, 178 (6): 3912-7. [PMID:17339491]
3. Fonseca FC, Orlando RM, Turchetti-Maia RM, de Francischi JN. (2017)
Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain.
J Inflamm Res, 10: 119-133. [PMID:28919798]
4. Jo YY, Lee JY, Park CK. (2016)
Resolvin E1 Inhibits Substance P-Induced Potentiation of TRPV1 in Primary Sensory Neurons.
Mediators Inflamm, 2016: 5259321. [PMID:27738388]
5. Uddin M, Levy BD. (2011)
Resolvins: natural agonists for resolution of pulmonary inflammation.
Prog Lipid Res, 50 (1): 75-88. [PMID:20887750]
6. Xu ZZ, Zhang L, Liu T, Park JY, Berta T, Yang R, Serhan CN, Ji RR. (2010)
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.
Nat Med, 16 (5): 592-7, 1p following 597. [PMID:20383154]