CXCL12α   Click here for help

GtoPdb Ligand ID: 4358

Synonyms: CXCL12 α | SDF-1α | stromal cell-derived factor-1α
Immunopharmacology Ligand
Comment: CXCL12-1α and β were the first isoforms of this chemokine identified. Both proteins contain a signal peptide sequence that mediates their secretion via the canonical intracellular secretory pathway. CXCL12 participates in a variety of processes central to homeostasis and physiology, exerting its biological effects by binding to the chemokine receptors CXCR4 and CXCR7.
Species: Human
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Immunopharmacology Comments
CXCL12 is involved in controlling the directional migration of leukocytes under normal and pathological conditions. Pharmacological inhibitors of the CXCL12-CXCR4/CXCR7 axis are being evaluated as novel anti-inflammatory agents [15]. There is evidence to suggest a role for CXCL12 and its receptors in cancer cell migration (metastasis) [5,8,10], and to indicate that disruption of the CXCL12-CXCR4 axis could be considered as a novel anti-HIV-1 mechanism [9].
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