Ligand id: 4358

Name: CXCL12α

Species: Human

Immunopharmacology Comments
CXCL12 is involved in controlling the directional migration of leukocytes under normal and pathological conditions. Pharmacological inhibitors of the CXCL12-CXCR4/CXCR7 axis are being evaluated as novel anti-inflammatory agents [15]. There is evidence to suggest a role for CXCL12 and its receptors in cancer cell migration (metastasis) [5,8,10], and to indicate that disruption of the CXCL12-CXCR4 axis could be considered as a novel anti-HIV-1 mechanism [9].
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