LIF

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Ligands
LIF (Human)

GtoPdb Ligand ID: 5016

Synonyms: cholinergic differentiation factor (CDF) | differentiation-inducing factor (DIF) | human interleukin in DA cells (HILDA)

Compound class: Endogenous peptide in human, mouse or rat

Comment: LIF is an IL-6 family cytokine.

Species: Human

Summary
Biological activity
Structure
Immunopharmacology

Immunopharmacology Comments
LIF is a Th2-type cytokine expressed by neurons, hepatocytes and kidney and breast epithelial cells. Its expression is upregulated by IL-4 and progesterone, and downregulated by inflammatory mediators including IFNγ.

Immunopharmacology Comments

LIF is a Th2-type cytokine expressed by neurons, hepatocytes and kidney and breast epithelial cells. Its expression is upregulated by IL-4 and progesterone, and downregulated by inflammatory mediators including IFNγ.