Immunopharmacology Comments

BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand) are two B cell-stimulating molecules critical for maintenance of the B cell pool and humoral immunity. Biological function and evidence of involvement in the pathogenesis of a number of human autoimmune diseases has lead to investigation of the potential of tageting these molecules as novel drug targets [7].

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Rheumatoid arthritis	Disease Ontology: DOID:7148 OMIM: 180300	BAFF is a drug target for RA.
Systemic lupus erythematosus	Disease Ontology: DOID:9074 OMIM: 152700 Orphanet: ORPHA536	BAFF is a drug target for SLE, as evidenced by the approval of the anti-BAFF mAb belimumab for the treatment of SLE.	4