BAFF   

GtoPdb Ligand ID: 5069

Synonyms: B cell-activating factor | CD257 antigen | dendritic cell-derived TNF-like molecule
Comment: The TNFSF13B precursor is also cleaved into a soluble form of the ligand.
Species: Human
Natural/Endogenous Targets
Target
BAFF receptor
B cell maturation antigen
TACI
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TACI Hs None - - - -
BAFF receptor Hs None - - - -
B cell maturation antigen Hs None - - - -
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
blisibimod Hs None Binding 11.4 pKd - 5
pKd 11.4 (Kd 4x10-12 M) [5]
Description: Binding to human AGP3 (=BAFF)
atacicept Hs None Binding 9.9 – 10.1 pKd - 6
pKd 9.9 – 10.1 (Kd 1.35x10-10 – 9x10-11 M) [6]
Description: Competitive binding to [125I]BAFF.
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
tibulizumab Hs Antibody Binding 10.2 pKd - 1
pKd 10.2 (Kd 6x10-11 M) [1]
tabalumab Hs Antibody Binding 8.0 pKd - 3
pKd 8.0 (Kd 1x10-8 M) [3]
belimumab Hs Antibody Binding 10.6 pEC50 - 2
pEC50 10.6 (EC50 2.4x10-11 M) [2]
Description: Binding affinity to immobilised BLyS