Fas ligand   Click here for help

GtoPdb Ligand ID: 5078

Synonyms: apoptosis antigen ligand | CD95L
Immunopharmacology Ligand
Comment: The TNFSF6 precursor is also cleaved into a soluble form of the ligand.
Species: Human
Immunopharmacology Comments
The Fas ligand (CD95L)/Fas receptor (CD95) interaction generates a death receptor/death ligand system that mediates apoptosis induction to maintain immune homeostasis. This system is also important in the immune elimination of virus-infected cells, cancer cells and autoreactive T cells. Mouse strains with mutations in Fas or CD95L develop lymphoproliferative conditions, indicating the importance of these proteins to immune cell homeostasis [2]. Fas or CD95L knockout mice show a more severe autoimmune phenotype than the mutant mice mentioned. Humans with type 1a and 1b autoimmune lymphoproliferative syndrome (ALPS) carry mutations in Fas and CD95L respectively.
Immunopharmacology Disease
Disease X-Refs Comment References
Autoimmune lymphoproliferative syndrome; ALPS Disease Ontology: DOID:6688
OMIM: 601859
Orphanet: ORPHA3261
Type 1b ALPS is caused by mutation of CD95L (Fas ligand). 1