5-LOX activating protein

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Ligands
5-LOX activating protein (Human)

GtoPdb Ligand ID: 5183

Abbreviated name: FLAP

Synonyms: 5-lipoxygenase-activating protein | arachidonate 5-lipoxygenase-activating protein

Compound class: Endogenous peptide in human, mouse or rat

Comment: FLAP is a scaffolding protein involved in leukotriene (eicosanoid proinflammatory mediator) biosynthesis. It has been investigated as a molecular target for novel anti-inflammatory drugs [3,5], in particular for airway inflammation [4,6].

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

Immunopharmacology Comments
FLAP acts as a scaffolding protein for the assembly of other enzymes involved in the leukotriene synthetic pathway. Compounds with FLAP inhibitory activity are expected to act as broad-spectrum leukotriene-modifiers, offering a wide range of therapeutic potential in inflammatory conditions [5]. For example GSK-2190915 has completed several Phase 2 clinical trials that evaluated its anti-asthmatic potential.

Immunopharmacology Comments

FLAP acts as a scaffolding protein for the assembly of other enzymes involved in the leukotriene synthetic pathway. Compounds with FLAP inhibitory activity are expected to act as broad-spectrum leukotriene-modifiers, offering a wide range of therapeutic potential in inflammatory conditions [5]. For example GSK-2190915 has completed several Phase 2 clinical trials that evaluated its anti-asthmatic potential.